Targeting PES1 for restoring the ERα/ERβ ratio in breast cancer.
نویسندگان
چکیده
Alteration of the ERα/ERβ balance is a critical step in breast cancer development and progression, and selective restoration of the activity of estrogen receptors has been proposed as one of the major therapeutic approaches for breast cancer. In this issue of JCI, Cheng et al. show that, by differentially modulating the stability of ERα and ERβ, PES1 increases the ERα/ERβ ratio and triggers breast tumor growth. These findings highlight PES1 as a potential target for the treatment of breast cancer.
منابع مشابه
PES1 promotes breast cancer by differentially regulating ERα and ERβ.
The initiation of breast cancer is associated with increased expression of tumor-promoting estrogen receptor α (ERα) protein and decreased expression of tumor-suppressive ERβ protein. However, the mechanism underlying this process is unknown. Here we show that PES1 (also known as Pescadillo), an estrogen-inducible protein that is overexpressed in breast cancer, can regulate the balance between ...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 122 8 شماره
صفحات -
تاریخ انتشار 2012